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. 2013 Sep 17;170(3):489–505. doi: 10.1111/bph.12111

Figure 7.

Figure 7

Proposed mechanisms for AEA-HO-1 signalling. AEA accumulates ROS, which induces Nrf2 nuclear translocation. Nrf2 transcriptionally activates ARE promoter of HO-1 or NQO-1. Under physiological conditions, HO-1 plays an important role in anti-inflammation, tissue injury and pain relief.