Figure 2.

Effects of single dosing of TAK-875 (TAK), metformin (MET) and TAK in combination with MET on fasting hyperglycaemia in aged ZDF rats. (A) and (B) show changes in plasma glucose and insulin levels, respectively, after single treatment with vehicle, 10 mg·kg⁻¹ of TAK, 150 mg·kg⁻¹ of metformin, or their combination. Data in (C) and (D) represent change in glucose AUC_{0–6 h} and change in insulin AUC_{0–6 h} respectively. **P ≤ 0.01 compared to vehicle-treated ZDF rats by Student's t-test or the Aspin–Welch test. The results of two-way anova are indicated in insets. Values are mean ± SD (n = 6). n.s., not significant.