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Dilatory responses to the IK/SK channel activator NS309 are preserved in transgenic mice. Concentration response curves of the IK/SK channel activator NS309 in PCA segments from WT, APP and TGF mice were comparable. The affinity of NS309 [pD2 value or −log (EC50)] at cerebrovascular channels was also comparable between all groups, with respective values of 7.58 ± 0.25, 7.99 ± 0.31 and 7.18 ± 0.29. Error bars represent SEM. n = 5 per group.
