Table 1.
Effects of HC (10−6 M) on cerebrovascular responses to ACh (10−4 M) in PCA segments from WT, APP, TGF and APP/TGF mice
| Treatment | WT (n = 6) | APP (n = 3) | TGF (n = 3) | APP/TGF (n = 3) | |
|---|---|---|---|---|---|
| EAmax | Control | 35.8 ± 1.9 | 25.2 ± 2.9 | 23.4 ± 3.1 | 18.3 ± 2.0 |
| HC | 16.2 ± 0.7a | 19.9 ± 2.0 | 19.3 ± 4.2 | 16.6 ± 2.4 | |
| pD2 | Control | 7.86 ± 0.10 | 7.95 ± 0.21 | 8.06 ± 0.23 | 8.16 ± 0.16 |
| HC | 6.34 ± 0.22a | 7.36 ± 0.21 | 8.02 ± 0.32 | 8.18 ± 0.23 |
Data are mean ± SEM of the number (n) of mice indicated in parentheses and are expressed as the maximal agonist response (EAmax, % dilation from induced tone) or potency [pD2 value or −log (EC50)]. HC had a significant effect only in WT mice.
a
P < 0.001 when compared to their respective control groups before HC treatment, by Student t-test.