Figure 3.

Mean number (±SEM) of gapes elicited by 0.1% saccharin solution previously paired with LiCl during the drug-free TR test trial. Only those pretreated with SR displayed potentiated gaping (**P < 0.025 relative to VEH-pretreated controls) during the drug-free test, suggesting that pretreatment during conditioning enhanced the nausea produced by LiCl. In contrast, 10 mg·kg⁻¹ THCV completely eliminated LiCl-induced gaping (***P < 0.001 relative to VEH) and 200 mg·kg⁻¹ CBDV, 2.5 mg·kg⁻¹ THC (*P < 0.05 relative to VEH) and 10 mg·kg⁻¹ THC (**P < 0.01), reduced LiCl-induced gaping during the drug-free test trial, suggesting that pretreatment during conditioning eliminated the nausea produced by LiCl.