Figure 3.

Effects of CBDV BDS modified and unmodified, and isobolographic study of CBDV and CBD. (A, B) Experiments 3.1–3.2: percentage of animals exhibiting each convulsion parameter (WR, wild running; clonic, clonic convulsions; tonic, tonic convulsions; chi-squared test, with post hoc Fisher exact test) for unmodified BDS (A) and modified BDS (B). (C–E) Experiments 3.3–3.4: isobolographic determination of CBDV and CBD interactions. (C) Dose–response relationships of CBD and CBDV. (D) ED₅₀ isobole of CBDV and CBD with theoretical and actual ED₅₀s marked (chi-squared test). (E) Results from co-administration study and predicted results based on individual pCB studies (two-way anova); n = 10; *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.