Modified and unmodified CBDV BDS, and purified cannabinoids in the acute pilocarpine model in rat. (A) Experiment 4.1: unmodified CBDV BDS. (B) Experiment 4.2: modified and unmodified CBDV BDS, and matched doses of pure CBDV and CBD. Both panels show maximum observed seizure severity (median severity in grey, box represents interquartile range, whiskers represent maxima and minima; Kruskal–Wallis test, with a post hoc Mann–Whitney U-tests). n = 15; #P ≤ 0.1, *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.