Table 1.
Experimental design and pCB content of in vivo Experiments 1.1–4.2
| Experiment/Figures | Compound | Doses (mg·kg−1) | CBDV/CBD content (mg·kg−1) | THC/THCV content (mg·kg−1) |
|---|---|---|---|---|
| Experiment 1.1, Figure 1A and 1B | Modified CBDV BDS | 50 | 29/7 | 0/0 |
| 100 | 58/14 | 0/0 | ||
| 200 | 116/27 | 0/0 | ||
| 275 | 159/38 | 0/0 | ||
| 346 | 200/47 | 0/0 | ||
| Experiment 1.2, Figure 1C and 1D | Purified CBDV | 50 | 50/0 | 0/0 |
| 100 | 100/0 | 0/0 | ||
| 200 | 200/0 | 0/0 | ||
| Modified CBDV BDS | 50 | 29/7 | 0/0 | |
| 100 | 58/14 | 0/0 | ||
| 200 | 116/27 | 0/0 | ||
| Experiment 1.3, Figure 1E and 1F | Purified CBDV + CBD | Low | 50/12 | 0/0 |
| Mid | 100/23 | 0/0 | ||
| High | 200/47 | 0/0 | ||
| Modified CBDV BDS | 50 | 50/12 | 0/0 | |
| 100 | 100/23 | 0/0 | ||
| 200 | 200/47 | 0/0 | ||
| Experiment 1.4, Figure 1G and 1H | pCB-free BDS | 50 | 2/<1 | 0/0 |
| 100 | 4/<1 | 0/0 | ||
| 200 | 9/<1 | 0/0 | ||
| Experiments 2.1 and 2.2, Figure 2A–F | Unmodified CBDV BDS | 150 | 71/21 | 2/4 |
| 275 | 130/38 | 3/7 | ||
| 422 | 200/59 | 4/11 | ||
| Modified CBDV BDS | 150 | 87/21 | 0/0 | |
| 275 | 159/38 | 0/0 | ||
| 346 | 200/47 | 0/0 | ||
| Experiment 3.1, Figure 3A | Unmodified CBDV BDS | 50 | 24/7 | 1/1 |
| 100 | 47/14 | 1/3 | ||
| 200 | 95/28 | 2/5 | ||
| Experiment 3.2, Figure 3B | Modified CBDV BDS | 50 | 29/7 | 0/0 |
| 100 | 58/14 | 0/0 | ||
| 200 | 116/27 | 0/0 | ||
| Experiment 4.1, Figure 4A | Unmodified CBDV BDS | 100 | 47/14 | 1/3 |
| 200 | 95/28 | 2/5 | ||
| 300 | 142/42 | 3/8 | ||
| Experiment 4.2, Figure 4B | Modified CBDV BDS | 200 | 116/27 | 0/0 |
| Unmodified CBDV BDS | 200 | 116/28 | 2/5 | |
| CBDV + CBD | – | 116/27 | 0/0 |