Table 2.
Displacement of [3H]CP55940 by (A) pure CBDV and unmodified CBDV BDS, and (B) unmodified CBDV BDS and modified CBDV BDS from specific binding sites on MF1 brain membranes
| Experiment | Compound | Ki (nM) (95% CL) | Maximum % displacement (95% CL) | n |
|---|---|---|---|---|
| A* | Pure CBDV | No plateau | – | 4 |
| A* | Unmodified CBDV BDS | 127.6 (52.5 and 310.2) | 113.6 (98.2 and 129.0) | 4 |
| B | Unmodified CBDV BDS | 722.6 (403.7 and 1293) | 98.6 (83.8 and 113.4) | 4 |
| B | Modified CBDV BDS | 1010 (223.5 and 4564) | 55.5 (33.4 and 77.6) | 4 |
*
Mean Ki and maximum % displacement values for pure CBDV and unmodified CBDV BDS in hCB1-CHO cell membranes were not significantly different from those obtained in MF1 whole mouse brain membranes (see Results and Figure 5A,B).
CL, confidence limit.