Table 3.
Displacement of [3H]CP55940 by (A) unmodified CBDV BDS and BDS-pCB + pure CBDV, (B) unmodified CBDV BDS and BDS-pCB + pure THCV, and (C) unmodified CBDV BDS and BDS-pCB + pure THC from specific binding sites on MF1 brain membranes
| Experiment | Compound | Ki (nM) (95% CL) | Maximum % displacement (95% CL) | n |
|---|---|---|---|---|
| A | Unmodified CBDV BDS | 300.8 (159.2 and 568.5) | 89.2 (78.7 and 99.7) | 4 |
| A | BDS-pCB + pure CBDV | 2151 (643.9 and 7184) | 80.2 (51.8 and 108.6) | 4 |
| B | Unmodified CBDV BDS | 363.9 (141.4 and 936.5) | 85.8 (70.4 and 101.3) | 4 |
| B | BDS-pCB + pure THCV | 960.0 (203.8 and 4523) | 73.0 (44.6 and 101.3) | 4 |
| C | Unmodified CBDV BDS | 604.5 (252.5 and 1447) | 99.5 (79.7 and 119.3) | 4 |
| C | BDS-pCB + pure THC | 861.7 (195.1 and 3805) | 86.5 (57.4 and 115.6) | 4 |
CL, confidence limit.