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. 2013 Oct 7;8(10):e74847. doi: 10.1371/journal.pone.0074847

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© 2013 Kooij et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The Ca²⁺-sensitivity derived from the midpoint of the force-pCa relationship (pCa₅₀) increased upon exchange with cTn (DD+PKCα) compared to failing cardiomyocytes exchanged with cTn (DD). *P<0.05, cTn (DD) exchange vs. cTn (DD+PKCα) exchange in ANOVA, followed by Bonferroni post-hoc test. Time control denotes results obtained from cardiomyocytes kept in exchange buffer without cTn complex added. (B) Subsequent incubation of PKCα of the cardiomyocytes exchanged with cTn (DD+PKCα) significantly reduced Ca²⁺-sensitivity of force development. *P<0.05 cTn (DD+PKCα) vs. cTn (DD+PKCα) + PKCα in paired t-test.