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. 2013 Oct 7;8(10):e74589. doi: 10.1371/journal.pone.0074589

Table 3. TREK family members expression in cancer.

Gene Cancer Subtype Above threshold analyses Median value
p-value Fold change % Ref p-value Gene rank n
KCNK2 Breast Invasive 5.70E-05 −2.23 4 [19] 0.349 8095 11
Lung Squamous cell 2.98E-04 2.111 5 [48] 0.696 6505 5
KCNK10 Brain Glioblastoma 1.81E-17 −4.843 5 [9] 5.03E-05 908 5
1.56E-10 −2.974 6 [10]
8.63E-04 2.547 7 [5]
Breast Ductal 1.00E-03 −2.294 2 [18] 0.15 6686.5 10
3.85E-04 −3.523 2 [14]
Colorectal Adenocarcinoma 1.74E-25 −7.227 1 [26] 8.12E-07 372.5 14
3.19E-22 −7.914 2 [26]
2.85E-18 −6.275 1 [26]
2.07E-14 −4.83 2 [26]
1.11E-07 −6.275 2 [26]
3.42E-07 −2.503 3 [26]

The above threshold data for TREK family members; KCNK2 and KCNK10 is shown. Data is divided into each cancer type and subtypes within that cancer. The p-value, fold change and gene rank percentile (%) for data which scored above threshold values (p-value<0.05, fold change >2 and gene rank percentile <10%) are shown. Comparative meta-analysis was performed using all available analyses for a given cancer subtype which provides median gene rank and median p-value. Overexpression ↑ and underexpression ↓ are indicated.