Table 3. TREK family members expression in cancer.

Gene	Cancer	Subtype	Above threshold analyses					Median value
				p-value	Fold change	%	Ref	p-value	Gene rank	n
KCNK2	Breast	Invasive	↓	5.70E-05	−2.23	4	[19]	0.349	8095	11
	Lung	Squamous cell	↑	2.98E-04	2.111	5	[48]	0.696	6505	5
KCNK10	Brain	Glioblastoma	↓	1.81E-17	−4.843	5	[9]	5.03E-05	908	5
			↓	1.56E-10	−2.974	6	[10]
			↑	8.63E-04	2.547	7	[5]
	Breast	Ductal	↓	1.00E-03	−2.294	2	[18]	0.15	6686.5	10
			↓	3.85E-04	−3.523	2	[14]
	Colorectal	Adenocarcinoma	↓	1.74E-25	−7.227	1	[26]	8.12E-07	372.5	14
			↓	3.19E-22	−7.914	2	[26]
			↓	2.85E-18	−6.275	1	[26]
			↓	2.07E-14	−4.83	2	[26]
			↓	1.11E-07	−6.275	2	[26]
			↓	3.42E-07	−2.503	3	[26]

The above threshold data for TREK family members; KCNK2 and KCNK10 is shown. Data is divided into each cancer type and subtypes within that cancer. The p-value, fold change and gene rank percentile (%) for data which scored above threshold values (p-value<0.05, fold change >2 and gene rank percentile <10%) are shown. Comparative meta-analysis was performed using all available analyses for a given cancer subtype which provides median gene rank and median p-value. Overexpression ↑ and underexpression ↓ are indicated.