Table 2. Evaluation of the progression of sporotrichosis caused by S. brasiliensis and S. schenckii in a subcutaneous murine model.
| Strain |
Dissemination
a
,
b
|
Secondary lesions | Deathc | Regression of the primary lesion | Observations | |
|---|---|---|---|---|---|---|
| Lung | Spleen | |||||
| Ss54 | ++ | ++ | 1/5 | 1/5 | 2/5 | Secondary open lesions along the tail; macroscopic lesions in the liver. |
| 5110 | ++ | ++ | 0/5 | 5/5 | 2/5 | Inflammation in the paw and posterior leg joints (arthritis); macroscopic lesions in the liver; all mice died within 60 days post-infection. |
| HUPE 114158 | ++ | ++ | 2/4 | 1/4 | 0/4 | Persistent cutaneous lesions (more than 80 days) |
| UFTM 01 | + | +/- | 3/5 | 1/5 | 1/5 | Persistent cutaneous lesions (more than 80 days); inflammation in the paw and joints (arthritis); macroscopic lesions in the liver. |
| HUPE 114500 | +/- | + | 1/5 | 0/5 | 0/5 | Persistent cutaneous lesions (more than 80 days) |
| IPEC 17943 | +/- | +/- | 0/5 | 0/5 | 4/5 | − |
| 1099-18 | + | + | 0/5 | 0/5 | 4/5 | − |
| IPEC 15383 | +/- | +/- | 0/5 | 0/5 | 4/5 | Secondary ulcerated lesions along the tail; inflammation in the posterior leg joints. |
a
Dissemination was determined by CFU in lung and spleen specimens collected 40 days post-infection.
b
Relative CFU counts (+/-) 20 colonies; (+) 20 to 120 colonies and (++) >120 colonies per Petri dish (the tissue specimens were ressuspended in the same proportion g tissue/mL).
c
Mortality up to 60 days post-infection.