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. 2013 Oct 7;8(10):e76286. doi: 10.1371/journal.pone.0076286

Figure 11. Docking of NMK-TD-100 to tubulin.

Figure 11

(A) In silico binding of NMK-TD-100 (yellow) on tubulin heterodimers. In the ribbon diagram grey represents α-tubulin monomer and blue represents β-tubulin monomer. (B) 3D diagram representing binding site of NMK-TD-100 on tubulin heterodimers. Red is showing the polar domains, blue stands for non-polar domains and white stands for neutral domains on protein surface. (C) Ball and stick figure showing positions of hydrogen bonds which stabilizes NMK-TD-100 molecule on protein surface. (D) The crystal structure of αβ heterodimer of tubulin depicting the proximity of the binding sites for colchicine (yellow) and NMK-TD-100 (red).