Table 1.
Population | |
No. of patients newly diagnosed with colorectal cancer | 140,000 |
No. of tumors tested for MSI | 140,000 |
No. of patients with MSI of tumor (12%) | 16,800 |
Search for mutations in MLH1, MSH2, MSH6 | 16,800 |
No. of patients with germline mutation (3%)= new HNPCC probands | 4,200 |
No. of relatives at risk tested (10 per proband; test for proband’s mutation only) | 42,000 |
No. of relatives with germline mutation (40%) | 16,800 |
Total no. of new cases of HNPCC (4,200 + 16,800) | 21,000 |