Table 1.
Compound | Yield (%) | IC50 valueb | Specific activityd | ||||
---|---|---|---|---|---|---|---|
| |||||||
MAO-A μM | MAO-B μM | DBH μM | MAO-A | MAO-B Unitc/g | DBH | ||
| |||||||
1 | 0.01 | 2,411 | 300 | 334 | 2,695 | 21,739 | 19,608 |
2 | 0.16 | >12,887 | 223 | >12,887 | <200 | 11,628 | <200 |
3 | 0.0003 | >9,363 | 127 | >9,363 | <200 | 14,706 | <200 |
4 | 0.0009 | 400 | 196 | 941 | 7,937 | 16,129 | 3,367 |
5 | 0.007 | >10,965 | 780 | 214 | <200 | 2,809 | 10,204 |
Iproniazida | - | 40 | 60 | - | |||
Deprenyla | - | 3.3 | 0.05 | - |
aPositive control for MAO. bInhibitory potency is obtained by Logic-log graph paper. cOne unit is defined as a sample amount to give 50% inhibition against the enzymes. dSpecific activity means the amount of unit in 1 g of a test sample.