Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Power for the conditional maternal-effects test (i.e., test 3, with 1 df), conditional on the genotypes of both grandparents and the affected grandchild. Scenarios are R1=1, R2=1, S1=2, and S2=4 (upper curve) and R1=1, R2=1, S1=2, and S2=2 (lower curve). (Calculations assumed a stratified population in which half have a baseline risk of 0.01 and an allele prevalence of 0.05 and the other half have a baseline risk of 0.03 and an allele prevalence of 0.10.)
