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The Dlx1/2 bigene cluster. (A) Dlx1 (dark blue) and Dlx2 (light blue) are oriented in an inverted configuration separated by two enhancers, I12a (black) and I12b (yellow). The lncRNA Dlx1as transcript (red) consists of two “exons” that are spliced and polyadenylated. (B) Whether Dlx1as is a key component of MLL1 function at the Dlx1/2 locus is not known.
