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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: J Pediatr Surg. 2013 Oct;48(10):2047–2053. doi: 10.1016/j.jpedsurg.2013.03.047

Table 1.

Gene expression of pertinent TGF-β related transcripts in Biliary Atresia patients with Fibrogenic or Inflammatory Gene Signatures.

GENE SYMBOL MECHANISM OF ACTION P-VALUE (Fibrogenic v. Inflammatory) FOLD CHANGE (Fibrogenic v. Inflammatory)
Intβ5 Activates TGF-β 0.010 1.23
Intβ8 Activates TGF-β 0.008 1.75
COL1A1 Increases collagen deposition 0.002 1.57
COL1A2 Increases collagen deposition 0.0005 1.31
COL3A1 Increases collagen deposition 0.0006 1.24
COL4A1 Increases collagen deposition 0.003 1.25
MMP7 Increases degradation of extracellular matrix 0.008 2.01
MMP9 Increases degradation of extracellular matrix 0.0001 −1.99
SERPINE1 (PAI-1) Inhibits degradation of extracellular matrix 0.0002 −2.91
*

Values shown represent the probeset with the most statistically significant difference between the two groups.