(A, B) Western blot examples and quantification reveal a down-regulation of glial glutamate transporters in the cortex of KO mice.
(C) Normalized glutamate uptake efficiencies in cortical slices of one-month-old wild-type and KO mice, with and without glial glutamate transporter inhibitors (DHK and TFB-TBOA).
(D) l-APV inhibition of eEPSCs is significantly reduced in KO cortical slices compared with wild-type slices.
(E) Percentages of spines eliminated over 4 days in wild-type mice with and without DHK treatment.
Data are presented as mean ± SEM. *P<0.05, **P<0.01. See also Figure S5.