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Our results lead us to propose a model in which binding of the activated Ecdysone hormone (20E) to EcR, and protein-protein interaction between EcR and Kdm4, promote H3K9 demethylation at the promoters of EcR target genes. The demethylation may be a consequence of sequence specific recruitment and targeting of Kdm4 by EcR, or a stimulation by EcR of the demethylase activity of Kdm4.
