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Roles for autophagy in regulating cell fate after DNA damage. We propose that after DNA injury, autophagy can influence cell fate, supporting or impairing cell survival. As a cytoprotective mechanism, autophagy may degrade pro-apoptotic proteins and membrane permeabilized mitochondria, enhance ATP and dNTPs generation for DNA repair and also regulate cell cycle arrest. However, autophagy may favor cell death through degradation of anti-apoptotic and DNA repair-related proteins
