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PARP-1 and p53 regulate each other activity. One of the many targets of PARP-1 is p53, covalently modifying the latter through poly(ADP-ribosyl)ation. On the other hand, p53 also regulates PARP-1 by modulating its activity. PARP-1 controls necrosis and p53 apoptosis after DNA damage, thus both types of cell death are well regulated
