Table 4.
EPSP in control aCSF followed by bath application of E2
| EPSP1 amplitude (mV) |
PPF |
EPSP1 half-width (ms) |
20–80% rise time (ms) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| aCSF | +E2 | % in E2 | aCSF | +E2 | % in E2 | aCSF | +E2 | aCSF | +E2 | |
| OVXControl + E2 | 2.6 ± 0.2 (14) | 3.3 ± 0.3** | 129 ± 6 | 1.94 ± 0.13 (13) | 1.68 ± 0.16 | 87 ± 7 | 48.2 ± 2.8 (12) | 48.2 ± 4.5 | 4.9 ± 0.2 (11) | 4.6 ± 0.2 |
| OVXControl + O | 2.9 ± 0.4 (19) | 3.7 ± 0.6** | 123 ± 7 | 1.86 ± 0.27 (17) | 1.77 ± 0.32 | 92 ± 5 | 53.1 ± 3.0 (19) | 55.8 ± 4.4 | 5.0 ± 0.2 (16) | 5.5 ± 0.4 |
| OVXLT + E2 | 3.1 ± 0.2 (17) | 4.3 ± 0.6* | 133 ± 13 | 1.98 ± 0.11 (13) | 1.89 ± 0.16 | 95 ± 5 | 49.5 ± 2.3 (17) | 51.2 ± 2.8 | 4.8 ± 0.2 (14) | 5.0 ± 0.3 |
| OVXLT + O | 2.5 ± 0.2 (16) | 2.3 ± 0.2 | 92 ± 7 | 2.11 ± 0.20 (16) | 2.23 ± 0.30 | 110 ± 7 | 49.1 ± 3.6 (15) | 55.0 ± 4.6 | 4.5 ± 0.2 (14) | 4.7 ± 0.3 |
*p ≤ 0.05 and **p ≤ 0.01, respectively, as compared with measures made in control aCSF for the same experimental group of rats. The numbers in the parentheses for EPSP1 amplitude measures refers to the numbers of independent CA3–CA1 pathways tested for individual groups, from the following number of rats and hippocampal slices: OVXControl + E2, three rats, 8 slices; OVXControl + O, five rats, 10 slices; OVXLT + E2, four rats, 11 slices; and OVXLT + O, three rats, 10 slices. The numbers in the parentheses for PPF measures are fewer than those for EPSP1 amplitude measures, as in some cases the second synaptic stimulus evoked APs instead of EPSPs following bath application of E2, and in others EPSPs were evoked with one rather than two synaptic stimuli. These experiments yielded no data on EPSP2 hence no PPF values.