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Modulation of Kv1.3 channel kinetics by sevoflurane. A–C, The effect of sevoflurane on activation (A), inactivation (B), and deactivation (C) kinetics of Kv1.3 current. D, Effect of 0.2 mm sevoflurane on peak IK+ conductance–voltage relationships and on steady-state inactivation of Kv1.3 channels. The data are fitted with a Boltzmann function, with values for V1/2 given in the Table (right).
