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. 2013 Sep 15;27(18):1974–1985. doi: 10.1101/gad.226613.113

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© 2013, Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 3.0 Unported), as described at http://creativecommons.org/licenses/by-nc/3.0/.

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Figure 3. — IDH2 mutant-induced AMLs display high 2-HG levels and altered DNA methylation and are chemoresistant. (A) 2-HG levels in BM, 32D, and MLL-AF9 or IDH2 mutant-induced AMLs. n = 3–5. (B) Representative dot blotting with antibodies against 5mC and 5hmC displaying DNA methylation of nonleukemic (BM and 32D) and leukemic cells. (C) Dose response of Nras^G12D;MLL-AF9, Nras^G12D;AML1-ETO, Nras^G12D;IDH2^R140Q, and Nras^G12D;IDH2^R172K leukemic cells to ara-C. Leukemic cells were treated with vehicle or 1–6000 nM ara-C for 3 d. n = 4. (D) Kaplan-Meier survival curve of mice transplanted with Nras^G12D;MLL-AF9 or Nras^G12D;IDH2^R172K leukemic cells treated with ara-C or vehicle. n = 5.