. Author manuscript; available in PMC: 2013 Oct 8.

Published in final edited form as: Exp Hematol. 2009 May 19;37(7):807–813.e2. doi: 10.1016/j.exphem.2009.04.005

Table 1.

Composite chromatin patterns across a large region correlate with specific changes in gene expression.

Expression Level gene (cells) ^*	Active Histone Marks	Silent Histone Marks	DNA Methylation
High	⁺	⁻	Hypomethylated
ε-globin (huES14:14) γ-globin (FL) β-globin (BM)	Extended Domain		Extended Domain
Low-Heterocellular	⁻	⁺	Heterogeneous
γ-globin (BM)		Localized to Promoter/gene
Low-Pancellular	⁺	⁺	Hypermethylated
β-globin (FL)	Localized to Promoter/gene	Localized to Promoter/gene
Silent	⁻	⁺	Hypermethylated
ε-globin (BM) β-globin (huES14:14)		Extended Domain

Examples of each expression level category are indicated below as ‘expressed gene (cell type)’

⁺

: presence of the modification, the extent of the mark is described

⁻

: absence of the modification