Table 2.
Immunohistochemical expression of p53 protein identified as positive, using automated cellular imaging system ACIS-III quantitative analysis, according to clinicopathological features of aggressiveness and patient outcome.
| Clinicopathological features (N) | Quantitative analysis of p53 protein | P-value | |
|---|---|---|---|
| Mean | Median | ||
| Gender (119) | |||
| Female (101) | 61.92 | 70.70 | 0.2940 |
| Male (18) | 53.96 | 53.35 | |
| Ethnicity (115) | |||
| White (111) | 77.59 | 83.42 | 0.5473 |
| Non-White (4) | 78.70 | 78.70 | |
| Age (119) | |||
| ≤45 years old (65) | 60.29 | 69.78 | 0.8791 |
| >45 years old (54) | 61.22 | 64.03 | |
| Smoking habit (65) | |||
| Smoker (24) | 73.65 | 78.89 | 0.3998 |
| Nonsmoker (39) | 78.43 | 84.84 | |
| Tumor size (119) | |||
| <2 cm (63) | 69.54 | 77.91 | 0.0015 |
| 2–4 cm (35) | 55.80 | 56.93 | |
| >4 cm (21) | 42.40 | 32.72 | |
| Extrathyroidal invasion (117) | |||
| Yes (60) | 57.26 | 57.12 | 0.0969 |
| No (57) | 65.73 | 78.72 | |
| Capsulation (102) | |||
| Yes (30) | 65.53 | 71.74 | 0.0762 |
| No (72) | 54.47 | 53.45 | |
| Multifocality (119) | |||
| Yes (45) | 53.27 | 55.08 | 0.0286 |
| No (74) | 65.24 | 74.14 | |
| Metastasis at diagnosis (119) | |||
| Present (43) | 51.34 | 46.01 | 0.0201 |
| Absent (76) | 66.02 | 75.75 | |
| Thyroiditis (119) | |||
| Present (39) | 69.38 | 78.72 | 0.0486 |
| Absent (80) | 56.49 | 57.12 | |
| Disease stage (TNM) (124) | |||
| I (79) | 62.23 | 70.70 | 0.6140 |
| II (13) | 58.32 | 74.44 | |
| III (15) | 51.35 | 53.59 | |
| IV (1) | 86.87 | — | |
| IVa (11) | 55.87 | 57.31 | |
| IVb (4) | 43.29 | 41.02 | |
| IVc (1) | 56.93 | — | |
| Outcome (109) | |||
| Free of disease (100) | 58.26 | 60.14 | 0.9605 |
| Recurrent (9) | 57.14 | 57.31 | |