TABLE 3.

Proteins differentially expressed in Min compared to wildtype with reduced statistical confidence

Protein name	Gene symbol	NCBI number	Log2 Area ratio Min/WTa	U-valuea	mRNA expression Min mouse (Tumor/Normal Epithelium)b	Microarray P-valueb
sulfhydryl oxidase 1 isoform a	Qsox1	NP_001020116.1	0.64	2.01E-07	Not Significant
complement factor I	Cfi	NP_031712.2	0.61	2.47E-03	Tumors up 879x	1.28E-09
C-reactive protein	Crp	NP_031794.3	0.26	5.05E-08	Not Significant
cathepsin E	Ctse	NP_031825.2	2.81	3.12E-03	Not Significant
coagulation factor V	F5	NP_032002.1	0.32	1.33E-07	Tumors up 6.3x	5.49E-04
serine protease inhibitor A3N	Serpina3n or Serpina3	NP_033278.2	0.38	4.68E-03	Tumors up 3.6x	3.54E-03
complement factor B isoform 1 specific	Cfb	NP_032224.2	0.61	3.95E-08	Not Significant
cathepsin B	Ctsb	NP_031824.1	0.49	8.27E-09	Tumors up 1.3x	9.84E-03
hemopexin	Hpx	NP_059067.2	1.50	4.34E-65	Tumors down 5.4x	1.23E-03
rho GDP-dissociation inhibitor 1	Arhgdia	NP_598557.3	−1.39	2.54E-03	Tumors up 1.4x	2.24E-03
afamin	Afm	NP_660128.2	−0.31	0.020	Tumors down 4x	6.79E-03
PREDICTED: aphrodisin	Obp1b, EG628991	XP_898907.3	−1.74	7.10E-19	Not detected
alpha-1B-glycoprotein	A1bg	NP_001074536.1	−2.92	2.74E-09	Not Significant
apolipoprotein C-I	Apoc1	NP_031495.1	−0.81	4.20E-04	Not Significant
collagen alpha-1(I) chain	Col1a1	NP_031768.2	−0.98	1.30E-06	Tumors up 5x	4.08E-04
platelet glycoprotein Ib alpha chain	Gp1ba	NP_034456.2	−0.74	9.27E-03	Not Significant
pyruvate kinase isozymes M1/M2	Pkm2	NP_035229.2	−1.10	2.27E-04	Not Significant

^aValue represents the the area ratio at 52 or 66 days with the lowest U-value. To see all area ratios and results, see the supplementary data.

^bSignificance was defined as a p-value of less than 0.05.