TABLE 4.
Proteins differentially expressed in Min compared to wildtype with no reciprocal metabolic label information or single hits
| Protein name | Gene symbol | NCBI number | Log2 Area ratio Min/WTa | U-valuea | mRNA expression Min mouse (Tumor/Normal Epithelium)b | Microarray P-valueb |
|---|---|---|---|---|---|---|
| glycosylation-dependent cell adhesion molecule 1 | Glycam1 | NP_032160.1 | 1.08 | 2.98E-06 | Not Significant | |
| heparin cofactor 2 | Serpind1 | NP_032249.3 | 0.84 | 1.13E-03 | Tumors up 21.5x | 3.86E-06 |
| lipopolysaccharide-binding protein | Lbp | NP_032515.2 | 0.60 | 7.62E-03 | Tumors up 6.4x | 1.18E-05 |
| alpha-1-acid glycoprotein 1 | Orm1 | NP_032794.1 | 0.78 | 2.74E-05 | Not Significant | |
| peptidase inhibitor 16 | Pi16 | NP_076223.3 | 0.48 | 3.62E-04 | Not Significant | |
| delta-aminolevulinic acid dehydratase | Alad | NP_032551.3 | 1.97 | 0.048 | Tumors up 1.5x | 2.25E-04 |
| fibrinogen-like protein 1 | Fgl1 | NP_663569.2 | 1.54 | N/A | Not Significant | |
| sialic acid binding Ig-like lectin G | Siglecg | NP_766488.2 | 1.48 | N/A | Tumors down 11x | 1.25E-05 |
| Hyaluronan and proteoglycan link protein 1 | Hapln1 | NP_038528.3 | 1.54 | N/A | Tumors down 3.6x | 1.55E-03 |
| ADP/ATP translocase 2 | Slc25a5 | NP_031477.1 | 1.10 | N/A | Tumors down 2.3x | 2.21E-06 |
| Contactin-4 | Cntn4 | NP_001103219.1 | 2.69 | N/A | Not Significant | |
| Syntaxin-1A | Stx1a | NP_058081.2 | 1.32 | N/A | Tumors up 19.8x | 4.36E-06 |
| Cadherin-2 | Cdh2 | NP_031690.3 | 1.17 | N/A | Not Significant | |
| Complement C1r subcomponent-like protein | C1rl | NP_851989.3 | 1.62 | N/A | Tumors down 1.6x | 1.46E-03 |
| Fatty acid-binding protein, heart | Fabp3 | NP_034304.1 | 1.18 | N/A | Not Significant | |
| Apelin | Apln | NP_038940.1 | −1.84 | N/A | Tumors up 55.5x | 7.40E-06 |
| Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 12 protein homolog | Als2cr12 | NP_780579.1 | 1.85 | N/A | Tumors down 14.6x | 2.87E-07 |
| Gamma enolase | Eno2 | NP_038537.1 | −1.18 | N/A | Not Significant | |
| Ubiquinone biosynthesis protein COQ9, mitochondrial | Coq9 | NP_080728.1 | −1.20 | N/A | Tumors down 2.4x | 1.32E-06 |
| Dipeptidyl peptidase 4 isoform 1 and 2 | Dpp4 | NP_034204.1 | −0.68 | N/A | Not Significant | |
| Pancreatic Lipase-related protein 1 | Pnliprp1 | NP_061362.1 | −1.93 | N/A | Tumors up 85x | 1.15E-08 |
| Hypothetical protein LOC72056 | 1810055G 02Rik |
NP_082353.1 | −5.44 | N/A | Tumors up 1.5x | 1.07E-02 |
| Chymotrypsin-like elastase family member 2A | Cela2a | NP_031945.1 | −1.14 | N/A | Not Significant | |
| Isocitrate dehydrogenase [NADP], mitochondrial | Idh2 | NP_766599.2 | −1.09 | N/A | Tumors up 2x | 3.15E-04 |
| Family with sequence similarity 148, member B | C2cd4b | NP_001074783.1 | −1.24 | N/A | Not Significant | |
| Coiled-coil domain-containing protein 39 | Ccdc39 | NP_080498.1 | −1.18 | N/A | Not Significant | |
| Thrombospondin type-1 | Thbs1 | NP_035710 | −1.32 | N/A | Tumors up 6.4x | 2.64E-04 |
| Tectonic 3 | Tctn3 | NP_080536.2 | −1.85 | N/A | Tumors up 3.7x | 4.52E-04 |
| extracellular superoxide dismutase [Cu-Zn] | Sod3 | NP_035565.1 | −0.66 | 3.21E-06 | Not Significant | |
| thrombospondin-4 | Thbs4 | NP_035712.1 | 0.57 | 1.45E-03 | Tumors down 19.7x | 2.09E-04 |
| leukemia inhibitory factor receptor isoform 2 | Lifr | NP_001106857.1 | −1.35 | 4.47E-03 | Tumors up 2.7x | 1.08E-05 |
| proteasome subunit alpha type-6 | Psma6 | NP_036098.1 | −0.78 | N/A | Tumors up 1.4x | 2.99E-05 |
| lymphocyte antigen 86 | Ly86 | NP_034875.1 | −1.66 | N/A | Not Significant | |
| receptor-type tyrosine-protein phosphatase mu | Ptprm | NP_033010.2 | −1.81 | N/A | Not Significant | |
| phosphoglycerate kinase 1 | Pgk1 | NP_032854.2 | −0.68 | N/A | Not Significant | |
| phospholipase A-2-activating protein | Plaa | NP_766283.2 | −1.25 | N/A | Tumors up 1.8x | 2.46E-03 |
a
Value represents the the area ratio at 52 or 66 days with the lowest U-value. To see all area ratios and results, see the supplementary data. Single hit proteins have no p-value and are indicated with “N/A”.
b
Significance was defined as a p-value of less than 0.05.