Table 5.
Comparison of protein and gene expression across the three studies
| Category | Protein/gene name | 14N/15N results | mRNAa | SRM Screen |
|---|---|---|---|---|
| Same expression change in all three screens | Inter-alpha-trypsin inhibitor heavy chain H3 | + | + | + |
| coagulation factor V | + | + | + | |
| Maltase-glucoamylase | − | − | − | |
|
| ||||
| Same expression change in two out of three screens | collagen alpha-1(I) chain | − | + | − |
| Leucine-rich alpha-2-glycorprotein | + | + | ||
| Fetuin B | + | + | ||
| Cathepsin B | + | + | ||
| Haptoglobin | + | + | ||
| Complement factor I | + | + | NS | |
| serine protease inhibitor A3N | + | + | ||
| Coagulation factor XIII B | − | − | ||
| afamin | − | − | ||
|
| ||||
| Data for only two studies where opposite expression is shown | Epidermal growth factor receptor | − | NI | + |
| Hemopexin | + | − | NS | |
| alpha-1 antitrypsin 1–5 | + | − | ||
| Serum amyloid P-component | + | − | ||
| Angiotensinogen | + | − | ||
| rho GDP-dissociation inhibitor 1 | − | + | ||
|
| ||||
| Data was only achieved for the 14N/15N study, but the proteins may be biologically significant | Cathepsin E | + | NS | |
| Alpha-2-macroglobulin | + | NS | ||
| Vitronectin | + | NS | ||
| pyruvate kinase isozymes M1/M2 | − | NS | NQ | |
| Vitamin D-Binding protein | + | NI | NS | |
| Inter-alpha-trypsin inhibitor heavy chain 4, isoform 1 | + | NS | ||
a
All other mRNAs for the differentially expressed proteins discovered in the 14N/15N were either not significant (NS) or not identified (NI).
NS=Not significant
NI=Not identified
NQ= Identified but not quantifiable