Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2013 Oct 8.

Published in final edited form as: Biochem Pharmacol. 2011 Feb 1;81(7):881–890. doi: 10.1016/j.bcp.2011.01.017

(A) Kaplan-Meier survival curves for patients with Mantle Cell Lymphoma based on the gene expression profile obtained from the LLMPP for Aurora kinase over-expressers (quartile 4) versus the lowest expressers (quartile 1) showing high expressers have a worse survival (months) for Aurora A (* p=8.0e-7) and B (** p=2.5e-5). (B) A representative TMA IHC staining demonstrating negative control, 1+, 2+ and 3+ staining for Aurora A and B (magnification 200× for all panels) by IHC. Positive Aurora (A or B) staining/total population evaluated is shown beneath each IHC panel. (C) Western blotting analysis demonstrated that Aurora A and B are over-expressed in a panel of aggressive B-cell NHL cell lines compared to the normal B-cells.

(A) Kaplan-Meier survival curves for patients with Mantle Cell Lymphoma based on the gene expression profile obtained from the LLMPP for Aurora kinase over-expressers (quartile 4) versus the lowest expressers (quartile 1) showing high expressers have a worse survival (months) for Aurora A (* p=8.0e-7) and B (** p=2.5e-5). (B) A representative TMA IHC staining demonstrating negative control, 1+, 2+ and 3+ staining for Aurora A and B (magnification 200× for all panels) by IHC. Positive Aurora (A or B) staining/total population evaluated is shown beneath each IHC panel. (C) Western blotting analysis demonstrated that Aurora A and B are over-expressed in a panel of aggressive B-cell NHL cell lines compared to the normal B-cells.

HHS Vulnerability Disclosure