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The TNF signalling pathway. DD: death domain; FADD: Fas-associated death domain; FAN: factor associated with neutral-sphingomyelinase; FLICE: FADD-like interleukin-1β-converting enzyme; JNK/SAPK: c-Jun N-terminal kinase/stress-activated protein kinase; MADD: MAPK-activating death domain; NF-κB: nuclear factor kappa B; NIK: NFκB-inducing kinase; RIP: receptor interacting protein; SMase: sphingomyelinase; TRADD: TNFR-associated death domain; TRAF-2: TNFR-associated factor-2.
