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CDF decreased the mRNA expression of EZH2, Notch-1, Nanog, and Oct4 in pancreatic tumor tissues (A), and increased miRNA expression of let-7a,b,c, miR-26a, and miR-10 in pancreatic tumors (B) derived from human pancreatic cancer MiaPaCa-2 cell-induced tumor implanted orthotopically in the pancreas of severe combined immunodeficient (SCID) mice, and real-time RT-PCR was carried out as described under the Materials and Methods section.
