Figure 5.

PrP-α3M>S mutants do not induce progressive neurodegeneration. (A) Adult females expressing PrP-WT (red) exhibit reduced survival compared with control flies expressing LacZ (green). Flies expressing either PrP-M205S (blue) or PrP-M205,212S (black) show similar longevity to control flies. (B) Adult females expressing PrP-WT (red) in motor neurons show 50% climbing by Day 2 and stop climbing by Day 10. Flies expressing PrP-M205S and PrP-M205,212S (black) show the same climbing ability as control flies expressing LacZ (green). ***P < 0.001