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PrP-M205,212S prevents the accumulation of Syx and Nrg in lipid rafts. Detection of proteins in lipid rafts. (A) PrP-WT, Syx and Nrg accumulate in lipid raft fractions (Fraction 3). (B) In flies expressing PrP-M205,212S, neither PrP and Syx, nor Nrg reach the lipid raft. As a control, we detected α-ATPase, a transmembrane protein that never accumulates in the lipid raft.
