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. 2013 Jun 13;22(21):4318–4328. doi: 10.1093/hmg/ddt281

Figure 6.

Figure 6.

Snord116del mice are leaner than WT littermates and have increased lipid oxidation during light hours. (A) Snord116del+/− gain weight at a slower rate than WT littermates and (B) are smaller as adults corresponding to decreased fat mass, lean mass and total body weight. (C) Snord116del+/− do not have altered food intake compared with WT littermates during light or dark hours. (D) Snord116del+/− mice exhibit lower RER during light hours when compared with WT mice. (E) Snord116del+/− mice have increased energy expenditure during light and dark hours (see also Supplementary Material, Fig. S4). Results are shown for male mice (n = 14 per group in A; WT, n = 12; Snord116del, n = 14 for B–E).