Table 2.
Demographics and patient characteristics
| NP-C positive (n = 3) | NP-C uncertain (n = 12) | NP-C negative (n = 235) | |
|---|---|---|---|
| Gender (male:female) | 1:2 | 8:4 | 161:74 |
| Age in years, median (range) | 43 (41–49) | 36 (22–57) | 38 (18–90) |
| Primary diagnosis, n | |||
| Psychosis | 0 | 9 | 153 |
| Early-onset progressive cognitive decline | 2 | 1 | 48 |
| Psychosis combined with early-onset progressive cognitive decline | 1 | 2 | 34 |
| Neurological symptoms, n | |||
| Presenta | 3 | 9 | 210 |
| Focal dystonia | 0 | 3 | 71 |
| Cerebellar ataxia | 2 | 3 | 66 |
| Dysarthria | 3 | 7 | 133 |
| VSGPb | 2 | 1 | 38 |
| Epilepsy | 0 | 2 | 65 |
| Cataplexy | 1 | 1 | 5 |
| Absent | 0 | 3 | 21 |
| Unknown | 0 | 0 | 4 |
| Visceral symptoms, n | |||
| Presenta | 1 | 1 | 32 |
| Hepatomegaly | 0 | 1 | 30 |
| Splenomegaly | 1 | 0 | 7 |
| Absent | 1 | 9 | 158 |
| Unknown | 1 | 2 | 45 |
aMultiple answers possible.
bVertical supranuclear gaze palsy (positive clinical assessment at baseline visit).