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. 2013 Dec;24(4):198–217. doi: 10.7171/jbt.13-2404-004

Table 1.

Targeted Genes, Annotations, and Number of HapTag SNPs Identified by Pairwise or Multimarker (multi) Algorithms at the Indicated Minor Allele Frequencies (MAFs) and Infinium (Inf) Design Scores ≥0.6

Gene symbol Genetic locus overlaps All HapTags: pairwise, MAF1% Inf 0.6+, pairwise, MAF1% Inf 0.6+, pairwise MAF5% Inf 0.6+, multi, MAF1% Inf 0.6+, multi, MAF5% Array coverage: multi HapTags, MAF1% Gene name Target categorya
A2BP1 1099 1046 914 710 599 full ataxin 2 binding protein 1 tum
ABCB1 91 81 62 62 44 full ATP binding cassette, subfamily B [multidrug resistance (MDR)/transporter associated with antigen processing (TAP)], member 1 tum
ABCC1 199 180 162 142 123 full ATP binding cassette, subfamily C [cystic fibrosis transmembrane conductance regulator (CFTR)/multidrug resistance-associated protein (MRP)], member 1 mut/PAH
ABCC2 51 44 33 40 29 full ATP binding cassette, subfamily C (CFTR/MRP), member 2 fol
ABCC4 355 324 274 244 199 full ATP binding cassette, subfamily C (CFTR/MRP), member 4 mut/PAH
ACHE 12 12 10 12 10 full ACETYLCHOLINESTERASE (YT BLOOD GROUP) nic
ADAM19 110 101 78 81 61 full a disintegrin and metalloprotease domain (ADAM) metallopeptidase domain 19 (meltrin β) adh
ADH1B 28 26 23 23 20 full alcohol dehydrogenase 1B (class I), β polypeptide tox
ADH7 49 47 40 40 33 full alcohol dehydrogenase 7 (class IV), μ or σ polypeptide tox
ADK 120 98 80 74 55 full adenosine kinase inf
AGER PPT2 23 22 20 22 17 full advanced glycosylation end product-specific receptor inf/mut
AHCY 17 12 12 8 8 full S-ADENOSYLHOMOCYSTEINE HYDROLASE fol
AHR 27 27 24 25 21 full ARYL-HYDROCARBON RECEPTOR PAH
AHRR 87 79 71 61 51 full ARYL-HYDROCARBON RECEPTOR REPRESSOR PAH
AKAP9 23 21 17 19 15 full A kinase (PRKA) anchor protein (yotiao) 9 tum
AKR1A1 17 13 10 12 7 full ALDO-KETO REDUCTASE FAMILY 1, MEMBER A1 (ALDEHYDE REDUCTASE) PAH
AKR1B10 30 25 24 22 21 full ALDO-KETO REDUCTASE FAMILY 1, MEMBER B10 (ALDOSE REDUCTASE-LIKE) onc
AKR1C1 AKR1C2 18 15 15 22 21 full ALDO-KETO REDUCTASE FAMILY 1, MEMBER C1 [DIHYDRODIOL DEHYDROGENASE 1; 20-α (3-α)-HYDROXYSTEROID DEHYDROGENASE] nit/PAH/str
AKR1C2 AKR1C1 46 38 36 24 23 full ALDO-KETO REDUCTASE FAMILY 1, MEMBER C2 (DIHYDRODIOL DEHYDROGENASE 2; BILE ACID BINDING PROTEIN; 3-α HYDROXYSTEROID DEHYDROGENASE, TYPE III) nit/PAH/str
AKR1C3 44 36 35 27 26 full ALDO-KETO REDUCTASE FAMILY 1, MEMBER C3 (3-α HYDROXYSTEROID DEHYDROGENASE, TYPE II) PAH/str
AKT1 16 13 12 13 12 full V-AKT MURINE THYMOMA VIRAL ONCOGENE HOMOLOG 1 onc
AKT2 15 14 11 13 10 full v-akt murine thymoma viral oncogene homolog 2 tum
AKT3 95 89 70 69 54 full v-akt murine thymoma viral oncogene homolog 3 (PKB, γ) tum
ALDH1L1 115 98 89 67 58 full aldehyde dehydrogenase 1 family, member L1 fo1
ALOX5 65 57 48 46 36 full ARACHIDONATE 5-LIPOXYGENASE inf/oxs
ALPL 100 96 88 79 70 dropped for capacity alkaline phosphatase, liver/bone/kidney
ANKK1 DRD2 44 41 33 26 19 full ANKYRIN REPEAT AND KINASE DOMAIN CONTAINING 1 nic
APEX1 30 29 26 26 22 full APEX NUCLEASE (MULTIFUNCTIONAL DNA REPAIR ENZYME) 1 DNA
AR 15 5 5 12 12 full ANDROGEN RECEPTOR (DIHYDROTESTOSTERONE RECEPTOR; TESTICULAR FEMINIZATION; SPINAL AND BULBAR MUSCULAR ATROPHY; KENNEDY DISEASE) str
AREG 31 14 12 10 7 full AMPHIREGULIN (SCHWANNOMA-DERIVED GROWTH FACTOR) onc
ARID1A 10 10 7 10 7 full AT RICH-INTERACTIVE DOMAIN 1A (SWI-LIKE) onc
ARNT 30 29 17 27 15 full ARYL-HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR PAH
ARNTL 103 98 88 84 75 full ARYL-HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR-LIKE PAH
ATIC 38 34 31 28 25 full 5-AMINOIMIDAZOLE-4-CARBOXAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE/IMP CYCLOHYDROLASE fol
BCL2 229 224 178 190 144 full B CELL chronic lymphocytic leukemia (CLL)/LYMPHOMA 2 onc
BDNF 33 33 26 30 23 full BRAIN-DERIVED NEUROTROPHIC FACTOR nic
BHMT 28 28 25 26 22 full BETAINE-HOMOCYSTEINE METHYLTRANSFERASE fol
BIRC5 21 19 18 17 16 full BACULOVIRAL inhibitor of apoptosis (IAP) REPEAT-CONTAINING 5 (SURVIVIN) onc
BMPR1B 210 199 180 143 125 full BONE MORPHOGENETIC PROTEIN RECEPTOR, TYPE IB onc
BRCA2 88 82 59 68 47 full breast cancer 2, early onset tum
C3 63 59 49 55 45 full COMPLEMENT COMPONENT 3 inf
CAMKK1 41 36 33 35 32 full calcium/calmodulin-dependent protein kinase kinase 1, α tum
CBR1 19 17 15 13 11 full CARBONYL REDUCTASE 1 nit/PAH
CBR3 16 13 11 11 9 full CARBONYL REDUCTASE 3 nit/PAH
CBS 60 57 53 47 43 full CYSTATHIONINE-β-SYNTHASE fol
CCL2 23 20 17 16 13 full chemokine (C–C motif) ligand 2 inf
CCL21 20 18 16 15 14 full chemokine (C–C motif) ligand 21 inf
CCL5 10 9 6 8 5 full chemokine (C–C motif) ligand inf
CCNA2 22 17 12 13 9 full cyclin A2 onc
CCND1 25 25 20 23 18 full CYCLIN D1 onc
CCND3 83 21 17 18 14 full cyclin D3 onc
CCR2 6 0 0 0 0 nine non-HapTag SNPs chemokine (C–C motif) receptor 2 inf
CD47 46 43 35 36 28 full CD47 ANTIGEN (RH-RELATED ANTIGEN, INTEGRIN-ASSOCIATED SIGNAL TRANSDUCER) adh
CDH1 66 56 53 50 47 full CADHERIN 1, TYPE 1, E-CADHERIN (EPITHELIAL) adh
CDKN2A 33 31 27 27 24 full cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) onc
CES3 10 8 5 7 4 full CARBOXYLESTERASE 3 tox
CHAT SLC18A3 85 98 81 112 93 full CHOLINE ACETYLTRANSFERASE nic
CHRNA3 CHRNA5 2 2 1 22 18 full CHOLINERGIC RECEPTOR, NICOTINIC, α 3 nic
CHRNA4 28 25 24 21 20 full CHOLINERGIC RECEPTOR, NICOTINIC, α 4 nic
CHRNA5 CHRNB4 28 26 21 13 10 full CHOLINERGIC RECEPTOR, NICOTINIC, α 5 nic
CHRNA7 89 85 71 76 62 full CHOLINERGIC RECEPTOR, NICOTINIC, α 7 nic
CHRNB2 24 23 22 20 18 full CHOLINERGIC RECEPTOR, NICOTINIC, β 2 (NEURONAL) nic
CHRNB3 21 20 17 16 13 full CHOLINERGIC RECEPTOR, NICOTINIC, β 3 nic
CHRNB4 CHRNA3 27 26 24 15 14 full CHOLINERGIC RECEPTOR, NICOTINIC, β 4 nic
CHUK 27 26 20 23 17 full CONSERVED HELIX-LOOP-HELIX UBIQUITOUS KINASE onc
CLOCK 35 29 27 20 18 full CLOCK HOMOLOG (MOUSE) onc
COL3A1 55 54 46 46 37 full COLLAGEN, TYPE III, α 1 (EHLERS-DANLOS SYNDROME TYPE IV, AUTOSOMAL DOMINANT) adh
COMT 56 49 43 39 34 full CATECHOL-O-METHYLTRANSFERASE PAH/str
CRP 31 31 23 25 18 full C-REACTIVE PROTEIN, PENTRAXIN-RELATED inf
CRY1 51 45 38 36 28 full CRYPTOCHROME 1 (PHOTOLYASE-LIKE) onc
CSNK1D 19 15 11 15 11 full CASEIN KINASE 1, δ onc
CTH 38 34 31 30 27 full CYSTATHIONASE (CYSTATHIONINE γ-LYASE) fol
CTLA4 27 27 24 18 15 full CYTOTOXIC T-LYMPHOCYTE-ASSOCIATED PROTEIN 4 inf
CTSD 9 8 7 8 7 full CATHEPSIN D (LYSOSOMAL ASPARTYL PEPTIDASE) tum
CYP17A1 24 19 15 16 12 full CYTOCHROME P450, FAMILY 17, SUBFAMILY A, POLYPEPTIDE 1 str
CYP19A1 112 104 94 75 65 full CYTOCHROME P450, FAMILY 19, SUBFAMILY A, POLYPEPTIDE 1 str
CYP1A1 CYP1A2 13 11 11 11 10 full CYTOCHROME P450, FAMILY 1, SUBFAMILY A, POLYPEPTIDE 1 PAH
CYP1A2 CYP1A1 13 13 10 11 9 full CYTOCHROME P450, FAMILY 1, SUBFAMILY A, POLYPEPTIDE 2 PAH
CYP1B1 41 38 34 33 28 full CYTOCHROME P450, FAMILY 1, SUBFAMILY B, POLYPEPTIDE 1 PAH
CYP21A2 15 7 5 7 5 full CYTOCHROME P450, FAMILY 21, SUBFAMILY A, POLYPEPTIDE 2 str
CYP2A13 11 7 6 7 6 full cytochrome P450, family 2, subfamily A, polypeptide 13 nit
CYP2A6 18 13 11 13 11 full CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6 nit
CYP2B6 43 34 31 27 23 full cytochrome P450, family 2, subfamily B, polypeptide 6 nit/tum
CYP2C9 32 28 20 26 18 full CYTOCHROME P450, FAMILY 2, SUBFAMILY C, POLYPEPTIDE 9 PAH
CYP2D6 11 5 5 5 5 full CYTOCHROME P450, FAMILY 2, SUBFAMILY D, POLYPEPTIDE 6 nit
CYP2E1 39 36 35 30 29 full cytochrome P450, family 2, subfamily E, polypeptide 1 nit
CYP3A4 30 24 18 23 17 full CYTOCHROME P450, SUBFAMILY IIIA (NIPHEDIPINE OXIDASE), POLYPEPTIDE 3 str
DBH 88 85 75 73 63 dropped for capacity DOPAMINE β-HYDROXYLASE (DOPAMINE β-MONOOXYGENASE)
DDX54 10 10 9 9 8 full DEAD (ASP-GLU-ALA-ASP) BOX POLYPEPTIDE 54 onc
DHFR 24 19 16 15 12 full DIHYDROFOLATE REDUCTASE fol
DMGDH 75 69 64 58 50 full dimethylglycine dehydrogenase fol
DNMT1 18 16 12 14 10 full DNA (cytosine-5-)-methyltransferase 1 fol
DNMT3A 56 54 44 45 35 full DNA (cytosine-5-)-methyltransferase 3 α fol
DNMT3B 58 56 46 40 30 full DNA (cytosine-5-)-methyltransferase 3 β fol
DRD2 ANKK1 53 53 45 44 36 full DOPAMINE RECEPTOR D2 nic
DRD4 11 11 10 10 9 full DOPAMINE RECEPTOR D4 nic
EGF 129 115 79 95 61 full epidermal growth factor tum
EGFR 212 196 167 162 135 full EPIDERMAL GROWTH FACTOR RECEPTOR (ERYTHROBLASTIC LEUKEMIA VIRAL (V-ERB-B) ONCOGENE HOMOLOG, AVIAN) onc
EGLN2 22 20 18 17 15 full egl nine homolog 2 oxs
EPHX1 36 26 23 26 22 full EPOXIDE HYDROLASE 1, MICROSOMAL (XENOBIOTIC) PAH
ERCC1 20 18 14 16 12 full EXCISION REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 1 (INCLUDES OVERLAPPING ANTISENSE SEQUENCE) DNA
ERCC2 34 33 22 30 20 full EXCISION REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 2 (XERODERMA PIGMENTOSUM D) DNA
ERCC3 39 36 25 32 20 full excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) DNA
ERCC4 61 55 39 41 26 full EXCISION REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 4 DNA
ERCC5 67 58 42 46 30 full EXCISION REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 5 [XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP G (COCKAYNE SYNDROME)] DNA
ERCC6 64 58 37 46 25 full excision repair cross-complementing rodent repair deficiency, complementation group 6 DNA
ERCC8 38 33 21 28 17 full EXCISION REPAIR CROSS-COMPLEMENTING RODENT REPAIR DEFICIENCY, COMPLEMENTATION GROUP 8 DNA
ESR1 341 237 173 182 126 full ESTROGEN RECEPTOR 1 str
ESR2 68 61 52 43 34 full ESTROGEN RECEPTOR 2 (ER β) str
EYA2 342 325 293 247 217 full eyes absent homolog 2 (Drosophila) DNA
FAM13A 165 156 138 113 93 full family with sequence similarity 13, member A mut
FCGR1A 8 1 1 1 1 full Fc fragment of IgG, high-affinity Ia, receptor (CD64) inf
FKBP5 53 30 22 24 18 full FK506 BINDING PROTEIN 5 inf/str
FMO3 46 42 34 34 26 full Flavin containing monooxygenase 3 tox
FOLH1 22 14 10 13 9 full FOLATE HYDROLASE (PROSTATE-SPECIFIC MEMBRANE ANTIGEN) 1 fol
FOLR1 FOLR2 5 5 4 8 6 full FOLATE RECEPTOR 1 (ADULT) fol
FOLR2 FOLR1 9 7 6 3 3 full FOLATE RECEPTOR 2 (FETAL) fol
FOLR3 23 13 12 9 9 full FOLATE RECEPTOR 3 (γ) fol
FPGS 23 20 17 19 16 full FOLYLPOLYGLUTAMATE SYNTHASE fol
FTCD 51 50 46 43 39 full formiminotransferase cyclodeaminase fol
GAB1 72 68 58 56 46 dropped for capacity growth factor receptor-bound protein 2-associated binding protein 1
GART 22 19 14 19 14 full PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE, PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE, PHOSPHORIBOSYLAMINOIMIDAZOLE SYNTHETASE fol
GATA3 63 62 50 58 45 full GATA BINDING PROTEIN 3 tum
GCLC 85 76 69 66 59 full GLUTAMATE-CYSTEINE LIGASE, CATALYTIC SUBUNIT oxs
GCLM 17 16 15 15 12 full GLUTAMATE-CYSTEINE LIGASE, MODIFIER SUBUNIT oxs
GDF15 18 16 15 15 14 full growth differentiation factor 15 onc
GGH 27 21 13 16 9 full γ-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) fol
GHR 93 84 72 66 55 full growth hormone receptor tum
GNMT 17 16 13 15 12 full glycine N-methyltransferase fol
GPC5 969 889 739 666 528 full glypican 5 mut
GPER 15 12 11 12 11 full GPCR 30 str
GPR126 70 63 52 54 44 85% GPCR 126 adh
GPX1 14 10 8 10 8 full GLUTATHIONE PEROXIDASE 1 oxs
GPX3 53 51 47 43 39 full GLUTATHIONE PEROXIDASE 3 (PLASMA) oxs
GRPR 13 13 13 22 22 full GASTRIN-RELEASING PEPTIDE RECEPTOR onc
GSK3B 71 58 44 48 35 full glycogen synthase kinase 3 β tum
GSR 49 42 32 37 27 full GLUTATHIONE REDUCTASE oxs
GSS 23 20 19 18 17 full GLUTATHIONE SYNTHETASE fol
GSTA1 16 11 9 10 8 full GLUTATHIONE S-TRANSFERASE A1 oxs/PAH
GSTA4 37 34 24 27 17 full GLUTATHIONE S-TRANSFERASE A4 oxs
GSTCD 39 37 27 29 18 full glutathione S-transferase, C-terminal domain containing fol
GSTM1 GSTM2 7 4 6 7 7 full GLUTATHIONE S-TRANSFERASE M1 oxs/PAH
GSTM2 GSTM1 15 12 10 10 8 full GLUTATHIONE S-TRANSFERASE M2 (MUSCLE) oxs/PAH
GSTM5 GSTM1 25 14 12 11 10 full GLUTATHIONE S-TRANSFERASE M5 oxs
GSTO1 33 30 24 28 23 full GLUTATHIONE S-TRANSFERASE ω 1 oxs
GSTP1 21 19 17 16 14 full GLUTATHIONE S-TRANSFERASE π 1 oxs/PAH
GSTT1 1 0 0 0 0 four non-HapTag SNPs GLUTATHIONE S-TRANSFERASE θ 1 oxs/PAH
HDC 38 36 33 32 29 full HISTIDINE DECARBOXYLASE inf
HELQ 40 37 31 26 20 full HELQ helicase, POLQ-like DNA
HFE 24 23 20 19 17 full HEMOCHROMATOSIS tox
HGF 83 78 59 64 46 full HEPATOCYTE GROWTH FACTOR (HEPAPOIETIN A; SCATTER FACTOR) onc
HHIP 43 43 37 35 28 dropped for capacity Hedgehog-interacting protein
hsa-mir21 97 full HOMO SAPIENS MICRORNA 21 onc
HSD11B1 39 37 35 29 27 full HYDROXYSTEROID (11-β) DEHYDROGENASE 1 nit/str
HSD17B1 17 14 12 13 11 full HYDROXYSTEROID (17-β) DEHYDROGENASE 1 str
HSD17B12 84 77 63 64 51 full HYDROXYSTEROID (17-β) DEHYDROGENASE 12 str
HSD17B3 63 56 46 45 35 full HYDROXYSTEROID (17-β) DEHYDROGENASE 3 str
HSD17B7 24 20 19 17 16 full HYDROXYSTEROID (17-β) DEHYDROGENASE 7 str
HSD3B1 20 16 16 11 11 full HYDROXY-δ-5-STEROID DEHYDROGENASE, 3 β- AND STEROID δ-ISOMERASE 1 str
HTR3E 24 22 18 20 16 full 5-hydroxytryptamine (serotonin) receptor 3, family member E nic
HTR4 126 115 105 89 81 full 5-hydroxytryptamine (serotonin) receptor 4 nic
ICAM1 26 25 21 25 21 full intercellular adhesion molecule 1 inf
ID2 13 13 11 12 11 full INHIBITOR OF DNA BINDING 2, DOMINANT NEGATIVE HELIX-LOOP-HELIX PROTEIN onc
IDH1 35 31 24 27 22 full ISOCITRATE DEHYDROGENASE 1 (NADP+), SOLUBLE onc
IER3 21 19 18 16 15 full immediate early response 3 mut/inf
IFNG 40 38 30 31 23 full IFN-γ inf
IGF1 65 57 38 48 30 full insulin-like growth factor 1 (somatomedin C) onc
IGF1R 318 306 272 239 206 full insulin-like growth factor 1 receptor onc
IGF2 TH 16 14 16 17 16 full insulin-like growth factor 2 (somatomedin A) onc
IGF2R 161 148 108 123 86 full insulin-like growth factor 2 receptor onc
IGFBP3 24 19 18 19 18 full INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 3 onc
IKBKB 25 24 18 20 15 full inhibitor of κ light polypeptide gene enhancer in B-cells, kinase β inf
IL10 34 30 24 28 21 full INTERLEUKIN 10 inf
IL1B 25 24 20 23 19 full interleukin 1, β inf
IL1RN 66 66 58 54 46 full interleukin 1 receptor antagonist inf
IL4 49 46 40 39 33 full INTERLEUKIN 4 inf
IL6 44 39 32 34 26 full INTERLEUKIN 6 inf
IL8 30 28 24 21 17 full interleukin 8 inf
IRS1 46 43 33 37 28 full INSULIN RECEPTOR SUBSTRATE 1 onc
JUN 19 18 16 17 15 full jun oncogene onc
KEAP1 11 9 9 9 9 full kelch-like ECH-associated protein 1 oxs
KLRK1 27 21 20 19 18 full KILLER CELL LECTIN-LIKE RECEPTOR SUBFAMILY C, MEMBER 4 adh
KRT18 15 10 7 10 7 full KERATIN 18 adh
KRT19 19 19 18 17 16 full KERATIN 19 adh
LTA TNF 10 9 10 19 10 full lymphotoxin α (TNF superfamily, member 1) inf
LTC4S 6 5 5 5 5 full LEUKOTRIENE C4 SYNTHASE inf
MAF 48 47 43 45 41 full v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian) onc
MAOA 19 19 19 22 22 full MONOAMINE OXIDASE A nic
MDM2 40 31 24 27 20 full MDM2, TRANSFORMED 3T3 CELL DOUBLE-MINUTE 2, P53 BINDING PROTEIN (MOUSE) DNA
MGMT 249 238 212 179 152 full O-6-METHYLGUANINE-DNA METHYLTRANSFERASE DNA/nit
MGST3 62 56 53 48 45 full MICROSOMAL GST 3 oxs
MIF 44 42 39 35 31 full macrophage migration inhibitory factor (glycosylation-inhibiting factor) inf
MSR1 99 94 81 79 68 full macrophage scavenger receptor 1 inf
MTAP 64 59 52 44 37 full methylthioadenosine phosphorylase fol
MT-COI 61 SNPs mitochondrially encoded cytochrome c oxidase I oxs
MTHFD1 36 32 29 31 28 full METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP+ DEPENDENT) 1, METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE, FORMYLTETRAHYDROFOLATE SYNTHETASE fol
MTHFR 36 32 29 26 22 full 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH) fol
MTHFS 57 53 47 35 29 full 5,10-METHENYLTETRAHYDROFOLATE SYNTHETASE (5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE) fol
MTR 79 64 49 42 33 full 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE fol
MTRR 54 49 36 34 22 full 5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE METHYLTRANSFERASE REDUCTASE fol
MUTYH 17 17 14 16 13 full MUTY HOMOLOG (Escherichia coli) DNA/oxs
MYBL2 34 32 26 24 18 full v-myb myeloblastosis viral oncogene homolog (avian)-like 2 tum
MYC 40 38 27 36 24 full V-MYC MYELOCYTOMATOSIS VIRAL ONCOGENE HOMOLOG (AVIAN) onc
NAT1 115 99 86 80 68 full N-ACETYLTRANSFERASE 1 (ARYLAMINE N-ACETYLTRANSFERASE) fol
NAT2 56 50 43 39 32 full N-ACETYLTRANSFERASE 2 (ARYLAMINE N-ACETYLTRANSFERASE) PAH
NCOA6 19 17 16 14 13 full NUCLEAR RECEPTOR COACTIVATOR 6 onc
NFE2L2 30 30 24 28 21 full NUCLEAR FACTOR (ERYTHROID-DERIVED 2)-LIKE 2 oxs
NFKB1 74 72 54 56 39 full NUCLEAR FACTOR OF κ LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS 1 (P105) inf/onc
NFKBIA 27 26 25 23 21 full NUCLEAR FACTOR OF κ LIGHT POLYPEPTIDE GENE ENHANCER IN B CELLS INHIBITOR, α inf/onc
NOS1 191 172 141 137 108 full NITRIC OXIDE SYNTHASE 1 (NEURONAL) inf
NOS2 56 53 51 47 44 full NITRIC OXIDE SYNTHASE 2A (INDUCIBLE, HEPATOCYTES) inf
NOS3 30 29 23 26 20 full NITRIC OXIDE SYNTHASE 3 (ENDOTHELIAL CELL) inf
NQO1 20 19 19 15 15 full NAD(P)H DEHYDROGENASE, QUINONE 1 oxs/PAH
NR1D2 27 22 18 21 17 full NUCLEAR RECEPTOR SUBFAMILY 1, GROUP D, MEMBER 2 onc
NR3C1 58 56 43 48 36 full nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) onc
NRIP1 85 33 30 30 26 full NUCLEAR RECEPTOR-INTERACTING PROTEIN 1 onc
NSD1 46 33 26 27 20 full NUCLEAR RECEPTOR BINDING SET DOMAIN PROTEIN 1 onc
OAS1 34 30 26 26 22 full 2′,5′-oligoadenylate synthetase 1, 40/46 kDa inf
OAS2 62 51 46 38 32 full 2′,5′-oligoadenylate synthetase 2, 69/71 kDa inf
OGG1 19 18 14 17 12 full 8-OXOGUANINE DNA GLYCOSYLASE DNA/oxs
OPRM1 209 174 149 139 115 full OPIOID RECEPTOR, μ 1 nic
PCDH7 179 174 143 135 109 full protocadherin 7 adh
PER1 14 14 11 14 11 full PERIOD HOMOLOG 1 (DROSOPHILA) onc
PGR 91 71 56 53 39 full PROGESTERONE RECEPTOR str
PHB2 9 9 8 9 8 full PROHIBITIN 2 adh/str
PID1 234 221 200 173 153 full Phosphotyrosine-interaction domain containing 1 inf
PIK3CG 47 45 36 31 22 full phosphoinositide-3-kinase, catalytic, γ polypeptide onc
PLA2G6 57 55 43 42 30 full phospholipase A2, group VI (cytosolic, calcium-independent) tum
PLEKHA6 134 126 120 90 85 full pleckstrin homology domain containing, family A member 6 nic
POLH 17 14 12 14 11 full POLYMERASE (DNA-DIRECTED), η DNA
POLI 19 18 10 18 10 full POLYMERASE (DNA-DIRECTED) ι DNA
POLK 39 35 26 34 25 full POLYMERASE (DNA-DIRECTED) κ DNA
POLL 20 19 15 18 13 full POLYMERASE (DNA-DIRECTED), λ DNA
PON1 67 66 59 56 48 full paraoxonase 1 tox
PPARG 113 107 80 83 60 full PEROXISOME PROLIFERATIVE ACTIVATED RECEPTOR, γ onc
PPARGC1B 150 141 132 112 102 full PEROXISOME PROLIFERATIVE ACTIVATED RECEPTOR, γ, COACTIVATOR 1, β onc
PPT2 AGER 18 18 14 15 13 full palmitoyl-protein thioesterase 2 tox
PTCH1 20 20 20 18 18 full patched homolog 1 tum
PTEN 30 28 20 27 18 full phosphatase and tensin homolog onc
PTGIS 65 59 47 57 44 dropped for capacity PG I2 (prostacyclin) synthase
PTGS1 73 70 54 61 47 full PG-endoperoxide synthase 1 (PG G/H synthase and cyclooxygenase) inf
PTGS2 29 24 19 19 14 full PG-ENDOPEROXIDE SYNTHASE 2 (PG G/H SYNTHASE AND COX) infl/oxs
RELA 13 13 11 12 10 full v-rel reticuloendotheliosis viral oncogene homolog A (avian) onc
RERGL 23 19 15 17 13 full RAS-like, estrogen-regulated, growth inhibitor (RERG)/RAS-like str
RNASEL 27 26 23 25 22 full ribonuclease L (2′,5′-oligoisoadenylate synthetase-dependent) inf
SELE 49 45 32 38 25 full selectin E inf
SERPINA3 40 39 37 37 34 full SERPIN PEPTIDASE INHIBITOR, CLADE A (α-1 ANTIPROTEINASE, ANTITRYPSIN), MEMBER 3 adh/onc
SHMT1 29 23 20 18 14 full SERINE HYDROXYMETHYLTRANSFERASE 1 (SOLUBLE) fol
SHMT2 8 6 6 6 6 full SERINE HYDROXYMETHYLTRANSFERASE 2 (MITOCHONDRIAL) fol
SLC18A3 CHAT 16 32 36 6 10 full SOLUTE CARRIER FAMILY 18 (VESICULAR ACETYLCHOLINE), MEMBER 3 nic
SLC19A1 31 29 26 25 22 full SOLUTE CARRIER FAMILY 19 (FOLATE TRANSPORTER), MEMBER 1 fol
SLC5A7 46 45 36 38 29 full SOLUTE CARRIER FAMILY 5 (CHOLINE TRANSPORTER), MEMBER 7 nic
SLC6A3 55 47 43 41 37 full SOLUTE CARRIER FAMILY 6 (NEUROTRANSMITTER TRANSPORTER, DOPAMINE), MEMBER 3 nic
SLC7A5 58 51 46 44 40 full SOLUTE CARRIER FAMILY 7 (CATIONIC AMINO ACID TRANSPORTER, Y+ SYSTEM), MEMBER 5 onc
SOD1 17 15 14 15 14 full SUPEROXIDE DISMUTASE 1, SOLUBLE [AMYOTROPHIC LATERAL SCLEROSIS 1 (ADULT)] inf
SOD2 17 15 13 13 11 full SUPEROXIDE DISMUTASE 2, MITOCHONDRIAL oxs
SOD3 25 21 18 20 16 full SUPEROXIDE DISMUTASE 3, EXTRACELLULAR inf
STC2 30 27 26 24 23 full STANNIOCALCIN 2 onc
SULT1A1 14 10 7 10 7 full SULFOTRANSFERASE FAMILY, CYTOSOLIC, 1A, PHENOL-PREFERRING, MEMBER 1 PAH
SULT1E1 54 49 28 43 22 full SULFOTRANSFERASE FAMILY 1E, ESTROGEN-PREFERRING, MEMBER 1 str
SULT2A1 28 26 24 21 18 full SULFOTRANSFERASE FAMILY, CYTOSOLIC, 2A, DEHYDROEPIANDROSTERONE (DHEA)-PREFERRING, MEMBER 1 str
TCN2 41 40 38 33 29 full TRANSCOBALAMIN II; MACROCYTIC ANEMIA fol
TEF 32 21 20 18 17 full THYROTROPHIC EMBRYONIC FACTOR onc
TFF1 72 64 57 49 43 full TREFOIL FACTOR 1 (BREAST CANCER, ESTROGEN-INDUCIBLE SEQUENCE EXPRESSED IN) onc
TFF3 46 44 39 39 35 full TREFOIL FACTOR 3 (INTESTINAL) onc
TGFA 136 129 107 109 87 full TRANSFORMING GROWTH FACTOR, α onc
TGFB1 19 19 17 18 16 full TRANSFORMING GROWTH FACTOR, β 1 (CAMURATI-ENGELMANN DISEASE) onc
TGFBR1 37 34 24 29 19 full TRANSFORMING GROWTH FACTOR, β RECEPTOR I (ACTIVIN A RECEPTOR TYPE II-LIKE KINASE, 53 KDA) onc
TH IGF2 28 26 20 20 18 full TYROSINE HYDROXYLASE nic
THSD4 594 558 498 428 364 full thrombospondin, type I, domain containing 4 adh/inf
TLR1 TLR6 20 20 17 23 19 full Toll-like receptor 1 inf
TLR10 35 30 24 21 17 full Toll-like receptor 10 inf
TLR2 23 20 20 19 19 full Toll-like receptor 2 inf
TLR4 58 56 43 50 38 full Toll-like receptor 4 inf
TLR5 14 12 12 0 0 13 pairwise HapTags Toll-like receptor 5 inf
TLR6 TLR1 32 12 9 9 6 full Toll-like receptor 6 inf
TNF LTA 20 17 6 4 3 full tumor necrosis factor inf
TNS1 154 151 133 135 114 dropped for capacity tensin 1
TP53 19 17 17 15 15 full TUMOR PROTEIN P53 (LI-FRAUMENI SYNDROME) onc
TP53BP1 25 23 18 20 15 full tumor protein p53 binding protein 1 onc
TYMS 31 28 26 24 22 full THYMIDYLATE SYNTHETASE fol
UGT1A1 UGT1A8 70 58 46 53 37 full UDP glucuronosyltransferase 1 family, polypeptide A cluster PAH
UGT1A8 UGT1A1 151 113 78 79 53 full UDP GLUCURONOSYLTRANSFERASE 1 FAMILY, POLYPEPTIDE A8 PAH
UGT2B10 21 10 9 9 8 full UDP GLUCURONOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE B10 nit/PAH
UGT2B11 18 10 9 10 9 full UDP GLUCURONOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE B11 nit/PAH
UGT2B15 1 0 0 0 0 nine non-HapTag SNPs UDP GLUCURONOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE B15 nit/PAH
UGT2B17 14 10 7 10 7 full UDP GLUCURONOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE B17 nit/PAH
UGT2B28 8 4 4 4 4 full UDP GLUCURONOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE B28 nit/PAH
UGT2B4 31 24 22 18 16 full UDP GLUCURONOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE B4 nit/PAH
UGT2B7 21 17 15 13 11 full UDP GLUCURONOSYLTRANSFERASE 2 FAMILY, POLYPEPTIDE B7 PAH
VCAM1 69 65 45 63 42 full vascular cell adhesion molecule 1 adh/inf
VEGFA 45 45 36 43 33 full VASCULAR ENDOTHELIAL GROWTH FACTOR A onc
VEGFB 15 15 15 12 12 full VASCULAR ENDOTHELIAL GROWTH FACTOR B inf
VEGFC 73 71 63 54 45 full VASCULAR ENDOTHELIAL GROWTH FACTOR C inf
XIAP 25 18 18 18 18 full BACULOVIRAL IAP REPEAT-CONTAINING 4 onc
XPA 34 31 25 26 20 full XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP A DNA
XPC 61 59 42 49 34 full XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C DNA
XRCC1 47 46 30 42 27 full X-RAY REPAIR COMPLEMENTING DEFECTIVE REPAIR IN CHINESE HAMSTER CELLS 1 DNA
XRCC4 134 120 94 94 68 full X-ray repair complementing defective repair in Chinese hamster cells 4 DNA
Sum: 17,797 15,961 13,474 12,926 10,511 Count: 298
a

adh, Adhesion molecules; DNA, repair of DNA damage; fol, folate transport and metabolism; inf, inflammatory signaling and processes or immune regulation; mut, mutagenic processes; nic, nicotine addiction and smoking behavior; nit, tobacco-specific nitrosamine (in particular, NNK) activation and detoxification; onc, oncogenesis; oxs, oxidative stress; str, steroid hormone metabolism and signaling; tox, other toxin or toxicity; tum, risk for lung cancer or related tumors.