Figure 1.

CTF8 genetic interactions. (A) Results from SGA analysis with ctf8Δ presented as a genetic interaction map. Lines represent a confirmed synthetic sick interaction between the connected genes. Broken lines represent synthetic lethal interactions. Gene functions are indicated. Genes required for efficient sister chromatid cohesion are indicated in bold. (B) Examples of tetrad analyses for a synthetic lethal interaction (ctf8Δ bim1Δ) and a synthetic sick interaction (ctf8Δ clb2Δ). Double mutants are indicated by the arrowheads.