Table 3.
Associations Between Interleukin-6 and Tumor Necrosis Factor α Receptor 2 and Risk of Invasive Epithelial Ovarian Cancer in the Nurses' Health Study (1989–2010) and Nurses' Health Study II (1996–2009)
| Biomarker and Quartile | Median Level, pg/mL | No. of Cases | No. of Controls | Relative Riska | 95% Confidence Interval | P-trend |
|---|---|---|---|---|---|---|
| Interleukin-6 | ||||||
| 1 | 0.67 | 58 | 128 | 1.00 | Reference | 0.69 |
| 2 | 1.03 | 45 | 128 | 0.75 | 0.46, 1.21 | |
| 3 | 1.56 | 56 | 128 | 0.93 | 0.58, 1.50 | |
| 4 | 3.11 | 56 | 129 | 0.85 | 0.52, 1.40 | |
| TNF-α-R2 | ||||||
| 1 | 1,934.25 | 41 | 129 | 1.00 | Reference | 0.08 |
| 2 | 2,360.20 | 53 | 130 | 1.34 | 0.81, 2.22 | |
| 3 | 2,770.80 | 61 | 130 | 1.48 | 0.89, 2.45 | |
| 4 | 3,475.60 | 61 | 129 | 1.57 | 0.92, 2.68 |
Abbreviation: TNF-α-R2, tumor necrosis factor α receptor 2.
a Adjusted for matching factors, batch, oral contraceptive use (never use, <5 years, or ≥5 years), tubal ligation (yes vs. no), parity (continuous), and body mass index (weight (kg)/height (m)2) at blood draw (continuous).