Figure 7.

Reduction of caudomedial neocortical areas in Dmrt5 mutants. Sagittal brain sections were analyzed by ISH for the indicated genes. (A–C) EphrinA5 domain of high expression and EphA7 domain of low expression that demarcate the somatosensory areas (delimitated by arrowheads) is contracted and detected in the most caudal part of the cortex in Dmrt5^−/− embryos. EphA7 and Cad8 high expression that mark the rostrally located motor area (with caudal limits indicated by arrowheads) occupies most of the reduced cortex in mutants. (D–F) RZRβ and Auts2 are expanded and p75 constricted caudally in mutants. Arrowheads mark the approximate caudal and rostral limit of their expression, respectively. Note the reduced EphA7 and p75 in the subplate. M, motor; S, somatosensory; sp, subplate; V, visual areas. Scale bars: 500 μm.