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. 2013 Oct 1;7:1103–1113. doi: 10.2147/DDDT.S48500

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© 2013 Ma et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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MicroRNA (miR-7 and miR-153) regulation of SNCA in PD.

Notes: The brain-enriched miRNAs, miR-7 and miR-153, are predicted to bind to the α-syn mRNA 3′-UTR as their targets. There is a significant synergy effect between miR-7 and miR-153 in down regulating α-syn mRNA levels and protein expressions. On the contrary, depletion of these miRNAs results in a concomitant increase in α-syn levels in a PD brain. miR-7 has a protective role by preventing oxidative stress and miR-7 inhibition causes cell death.

Abbreviations: 3′-UTR, 3′ untranslated region; α-syn, α-synuclein; mRNA, messenger RNA; miRNA, microRNA; PD, Parkinson’s disease.