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LRRK2 regulates the microRNA (let-7 and miR-184*) network.
Notes: Pathogenic LRRK2 inhibited let-7 and miR-184* function and consequently transcription factors E2F1 and DP were upregulated, and such effects were dependent on LRRK2 kinase activity. Overexpression of E2F1 and DP may lead to dopamine neuron degeneration and impaired locomotor activity.
Abbreviation: LRRK2, leucine-rich repeat kinase 2.
