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. 2013 Oct 1;7:1103–1113. doi: 10.2147/DDDT.S48500

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© 2013 Ma et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The role of PARK2 and PARK7 in the pathogenesis of PD.

Notes: In accordance with numerous studies, the genes PARK2 and PARK7 are also involved in the pathogenesis of PD. PARK2 encodes the parkin protein, and the DJ-1 protein is encoded by PARK7. In the brains of PD patients, the levels of miR-34b and miR-34c are significantly decreased, decreased levels of miR-34b and miR-34c are also accompanied by decreased concentrations of parkin and DJ-1 proteins. Nevertheless, there is no experimental evidence for miR-34b/miR-34c targeting to genes encoding parkin and DJ-1.

Abbreviation: PD, Parkinson’s disease.