Table 1.

miRNAs potentially involved in PD pathophysiology

miRNA	Target genes	Function	Reference
miR-7	SNCA	Downregulate α-synuclein expression in nervous system, protect cells against oxidative stress	34
miR-153	SNCA	Directly reduce SNCA protein expression. miR-7 and miR-153 are synergistic in their effect	35
let-7	E2F1a, pdr-1	Co-underexpress in the alpha-synuclein and pdr-1 strains; influence on pathogenicity of mutant LRRK2 via E2F1 and DP	48,106
miR-184*	DPa	Regulate DAb neurons survival and activity: influence on pathogenicity of mutant LRRK2 via E2F1 and DP	48
miR-34b	Not found	Regulate expression of DJ1 and Parkin, two proteins associated to familial forms of PD	66
miR-34c	Not found	Regulate expression of DJ1 and Parkin, two proteins associated to familial forms of PD	66
miR-133b	Pitx3c	Regulation of maturation and functioning of midbrain dopaminergic neurons within a negative feedback circuit	69
miR-433	FGF20d	Increase translation of FGF20, which is correlated with increased α-synuclein expression	83

Notes:

^aE2F1 and DP (transcription factors);

^bDA (dopaminergic);

^cPitx3 (pituitary homeobox 3);

^dFGF20 (fibroblast growth factor 20).

Abbreviations: DA, dopaminergic; FGF20, fibroblast growth factor 20; LRRK2, leucine-rich repeat kinase 2; Pitx3, pituitary homeobox 3; PD, Parkinson’s disease.