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. 2013 Oct 8;8(10):e76947. doi: 10.1371/journal.pone.0076947

Figure 5. BMP7 preferentially utilizes Alk2 in Bmpr2 Δtd/+ PaSMCs.

Figure 5

(A) The ability of BMP4 or BMP7 (10 ng/ml for 1.5 h) to induce Id1 and Smad6 gene expression, in Bmpr2 Δtd/+ PaSMCs deficient in Alk2 or expressing Alk2 was examined by qPCR. Id1 and Smad6 gene expression was normalized to Gapdh and expressed as fold-change relative to Bmpr2 Δtd/+ ; Alk2 flox/flox PaSMCs. *P < 0.01 compared to Bmpr2 Δtd/+ ; Alk2 flox/flox PaSMCs treated with BMP7. (B) The ability of BMP4 or BMP7 (10 ng/ml for 1.5 h) to induce Id1 and Smad6 gene expression, in Bmpr2 Δtd/+ PaSMCs deficient in Alk3 or expressing Alk3 was measured by qPCR. Id1 and Smad6 gene expression was normalized to Gapdh and expressed as fold-change relative to Bmpr2 Δtd/+ ; Alk3 flox/flox PaSMCs. *P < 0.01 compared to Bmpr2 Δtd/+ ; Alk3 flox/flox PaSMC treated with BMP4.