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. 2013 Oct 8;8(10):e76830. doi: 10.1371/journal.pone.0076830

Figure 4. The potency of DOX resistance of the JHH-6 subpopulations CD90+ and CD90-.

Figure 4

A. Cells viability against DOX (0-40 µg/ml) for 24 hours assessed by MTT assay. Non-treated cells were considered as 100% viability (Students’ t test *p<0.05). The data represented the mean ± SD of three independent experiments. B. The mRNA and protein expression of DOX-related ABC transporters ABCB1, ABCCC1, and ABCG2 genes (Students’ t test *p<0.05 compared to CD90-). Low panel: WB analysis of each proteins ABCG2 (72 kDa), ABCB1 (170-190 kDa), and ABCC1 (140 kDa) together with ATP1A1 membrane protein (112 KDa).