Figure 2. Example of a high-risk Alzheimer’s disease mortality pedigree.

Squares are males, circles are females, and diamonds are gender-censored (unspecified gender) individuals. Individuals with a diagonal line are deceased, and shaded shapes are Alzheimer’s disease cases; unaffected siblings are not shown. The founder has more than 4,100 descendants; 11 died from Alzheimer’s disease, only 3.2 Alzheimer’s disease deaths were expected (p= 0.0031).