Table 2. Characteristics of studies for association between mbl2 polymorphisms and HBV infection.

Study	Ethnicity	Control	Cases	Polymorphisms included	Genotyping Methods	HWE
Thomas HC 1996 [8]	Caucasian	HC/SR	CHB	Condon52, 54 and57	SSOP; sequencing	No
	Asian	HC	CHB	Condon52, 54 and57	SSOP; sequencing	Yes
Bellamy R 1998 [9]	African	HC/SR	CHB	Condon52, 54 and57	SSOP	Yes
Höhler T 1998 [10]	Caucasian	HC/SR	CHB	Condon52 and 54	PCR-RFLP	Yes
Yuen MF 1999 [11]	Asian	HC	CHB/LC/HCC	Condon54	PCR-RFLP	−
Shi H 2001 [12]	Asian	HC	CHB	Condon52, 54 and 57	PCR-RFLP	Yes
Hakozaki Y 2002 [13]	Asian	HC	SHB	Condon52, 54 and 57; -221Y/X	sequencing	No
Song le H 2003[1]	Asian	HC	CHB/LC/HCC	Condon52, 54 and57	sequencing	Yes
Cheong JY 2005 [14]	Asian	SR	CHB	Condon54	SBE	Yes
Thio CL 2005[15]	A mixed population	SR	CHB	Mbl2 promoter and exon1 combined polymorphisms	Real time PCR	−
Chong WP 2005 [16]	Asian	HC/SR	CHB/LC/HCC	Mbl2 promoter and exon1 combined polymorphisms	TaqMan PCR	Yes
Segat L 2008 [17]	Caucasian	HC	HCC	Condon52, 54 and57	Real time PCR	Yes
Tong FY 2008 [18]	Asian	HC	CHB/SHB	Condon52, 54 and 57	sequencing	−
Filho RM 2010 [19]	A mixed population	HC	CHB	Condon52, 54 and 57; -221Y/X	Taqman PCR	Yes
Fletcher GJ 2010 [20]	A mixed population	SR	CHB	Condon52, 54 and 57; -221Y/X	PCR-SSP	−
Chen DQ 2010 [21]	Asian	SR	CHB	Condon54 and -221Y/X	PCR-RFLP	Yes
Chatzidaki V 2012 [22]	Caucasian	HC/SR	CHB	Condon54 and 57; -221Y/X	PCR-RFLP	Yes
Zheng RD 2012 [23]	Asian	HC/SR	CHB/SHB/LC	Condon54	PCR-RFLP	Yes

RFLP: restriction fragment length polymorphisms; SSOP: sequence specific oligonucleotide probes; PCR-SSP: polymerase chain reaction-sequence specific primer; SBE: Single Base Primer Extension Assay. HWE: Hardy-Weinberg equilibrium; − not available. HC: healthy control; SR: spontaneous recovered control; CHB: chronic hepatitis B; LC: liver cirrhosis; HCC: hepatocellular carcinoma; SHB: severe hepatitis B.